The white space incumbents leave open.
Measure, or don't ship.
A score earns its place only after it survives validation, and it always travels with its uncertainty.
A modest disclosed correlation, not a miracle.
Calibrated on known actives, interval always shown.
We say so when a chemotype is one the model has never seen.
Transparency is the differentiator. Our metrics are public, measured, and disclosed, including where they're weak.
Four of these five made our published numbers worse. We shipped them anyway.
Near-constant, correlated ≈ 0 with lifespan. Dropped.
Our standardizer handed leave-one-out a free perfect match.
It scored aspirin 0.958 against BCL-2. Rebuilt.
Novel molecules labelled "already known". Fixed.
3D shape + electrostatics, beaten by plain 2D.
None of these were forced on us. Every one was found internally and could have been left alone. A number that only ever moves upward is not a measured number.
From target to synthesizable candidate.
Pick target + tissue
Built from real building blocks via named reactions. The route exists by construction.
→Score on aging biology
12 hallmarks, measured-lifespan compounds, ADMET and binding plausibility.
→Read the confidence
Every number ships with its interval and its disclosed accuracy.
→Hand it to a chemist
Export with explicit routes and provenance. A starting point, not an oracle.
Deterministic and auditable. The same inputs give the same outputs on every run, with a registration hash per candidate. We cite the published methods we build on; our specific calibrations stay ours, and can be reviewed under NDA.
Two chemists, building the longevity design tool they wanted.
Builds the platform. The de novo engine, scoring stack, and product.
Drives the chemistry, medicinal-chemistry judgement and candidate evaluation.
Geroscience advisors, introductions welcome.
What we build on, and what stays yours.
Public, citable data
DrugAge · ChEMBL · GTEx · López-Otín hallmarks. Lineage inspectable, not invented.
Nothing to set up
No install, no procurement, no training run to budget for. Send a target, get dossiers.
Deterministic & auditable
Same inputs, same outputs. Registration hash per candidate, versioned scoring.
Your chemistry stays yours
We never train on your inputs. Cloud, private VPC or on-prem; DPA available.